Effect of liposomal drug based on interferon and extract from Silybum marianum on antioxidative status of bulls against the background of contamination of fodders by cadmium and plumbum

The balance between anti- and prooxidants in animal organisms general each cell particular is responsible for the regulation of many metabolic processes that provide immunocompetence, growth, development protection animals from oxidative stress, related to inflow cadmium plumbum. Therefore, objective our study was influence a liposomal drug based on interferon milk thistle (Silybum marianum (L.) Gaertn.) antioxidative status organism bulls conditions plumbum loading. experiments were performed six-months-old Black Motley dairy cattle. fodders farm determined contain high levels cadmium. Lipointersyl inhibited lipid peroxidation bulls. components promoted decrease level intermediate end products peroxidation, 22% diene conjugates 20% TBA-active products. Intramuscular injection experimental group strengthened antioxidant their organism. On 30th day experiment, blood seen have 9.8% increase reduced glutathione. Assay enzymatic link glutathione system revealed activity peroxidase reductase had been injected Lipointensyl increased by 24.0% 27.7% respectively experiment. conducted young cattle demonstrated intermuscularly – against background loading activation as result its non-enzymatic links. catalase superoxide dismutase activities 40th days those enzymes varied within physiological norms. analyzed Silybum marianum-based has properties, it recommended contamination with heavy metals order prevent stress.